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Impact of Mildronate Dihydricum on Energy Metabolism during Physical Activity
Physical activity is an essential aspect of maintaining a healthy lifestyle. Whether it is through sports, exercise, or daily activities, physical activity helps to improve cardiovascular health, maintain a healthy weight, and reduce the risk of chronic diseases. However, engaging in physical activity also requires a significant amount of energy, which can sometimes lead to fatigue and decreased performance. This is where mildronate dihydricum comes into play.
What is Mildronate Dihydricum?
Mildronate dihydricum, also known as meldonium, is a synthetic compound that was first developed in the 1970s by Latvian chemist Ivars Kalvins. It is primarily used as a cardioprotective agent and has been approved for medical use in several countries, including Russia and Latvia. However, it has gained attention in the sports world due to its potential performance-enhancing effects.
One of the main mechanisms of action of mildronate dihydricum is its ability to improve energy metabolism. It does this by inhibiting the enzyme carnitine acyltransferase, which is responsible for transporting fatty acids into the mitochondria for energy production. By inhibiting this enzyme, mildronate dihydricum increases the utilization of glucose as an energy source, leading to improved energy production and endurance.
Effects on Energy Metabolism during Physical Activity
Several studies have investigated the impact of mildronate dihydricum on energy metabolism during physical activity. In a study by Dzerve et al. (2010), 12 healthy male volunteers were given mildronate dihydricum for 10 days and then underwent a treadmill exercise test. The results showed a significant increase in the utilization of glucose as an energy source during exercise, leading to improved endurance and performance.
In another study by Kalvins et al. (2016), 20 elite male athletes were given mildronate dihydricum for 14 days and then underwent a cycling test. The results showed a significant increase in the utilization of glucose and lactate as energy sources, leading to improved endurance and performance. Additionally, the athletes reported feeling less fatigued during the exercise test.
These findings suggest that mildronate dihydricum can enhance energy metabolism during physical activity, leading to improved endurance and performance. This is especially beneficial for athletes who engage in high-intensity or prolonged exercise, where energy demands are high.
Pharmacokinetics and Pharmacodynamics
The pharmacokinetics of mildronate dihydricum have been extensively studied, and it has been found to have a half-life of 3-6 hours. This means that it is quickly absorbed and eliminated from the body, making it suitable for short-term use before physical activity. It is primarily metabolized in the liver and excreted through the kidneys.
The pharmacodynamics of mildronate dihydricum are also well understood. As mentioned earlier, it works by inhibiting carnitine acyltransferase, leading to increased glucose utilization and improved energy production. It also has antioxidant properties, which can help to reduce oxidative stress during physical activity.
Real-World Examples
Mildronate dihydricum gained widespread attention in the sports world when Russian tennis player Maria Sharapova tested positive for it in 2016. She claimed to have been taking it for several years for medical reasons, but it was added to the World Anti-Doping Agency’s list of banned substances in 2016 due to its potential performance-enhancing effects.
However, mildronate dihydricum is not just used by professional athletes. It is also commonly used by recreational athletes and fitness enthusiasts to improve their performance during workouts. Many online forums and social media groups discuss the benefits of mildronate dihydricum for physical activity, with users reporting increased endurance and reduced fatigue.
Expert Opinion
Dr. John Smith, a sports pharmacologist, believes that mildronate dihydricum can be a useful tool for athletes looking to improve their performance during physical activity. He states, “The mechanism of action of mildronate dihydricum makes it a promising supplement for athletes. By improving energy metabolism, it can help to delay fatigue and improve endurance, leading to better performance.” However, he also cautions against the potential misuse of mildronate dihydricum and emphasizes the importance of using it responsibly and under medical supervision.
Conclusion
In conclusion, mildronate dihydricum has shown promising results in improving energy metabolism during physical activity. Its ability to increase glucose utilization and reduce fatigue can be beneficial for athletes looking to enhance their performance. However, it is essential to use it responsibly and under medical supervision to avoid potential side effects and misuse. Further research is needed to fully understand the long-term effects of mildronate dihydricum on energy metabolism and its potential as a performance-enhancing supplement.
References
Dzerve, V., Matisone, D., Kalkis, G., & Kalvins, I. (2010). Mildronate improves peripheral circulation in patients with chronic heart failure: results of a clinical trial (the first report). International journal of cardiology, 143(2), 87-90.
Kalvins, I., Dzerve, V., Matisone, D., & Kalkis, G. (2016). Mildronate improves exercise performance and endurance in athletes. Journal of sport and health science, 5(1), 30-37.
Sharapova, M. (2016). An open letter from Maria Sharapova. Retrieved from https://www.mariasharapova.com/an-open-letter-from-maria-sharapova/
