-
Table of Contents
Finasteride and Its Action on the Central Nervous System During Physical Activity
Finasteride, also known by its brand name Propecia, is a medication primarily used to treat male pattern hair loss and benign prostatic hyperplasia (BPH). However, recent studies have shown that finasteride may also have an impact on the central nervous system (CNS) during physical activity. This has sparked interest in the sports pharmacology community, as it could potentially enhance athletic performance. In this article, we will explore the pharmacokinetics and pharmacodynamics of finasteride and its potential effects on the CNS during physical activity.
Pharmacokinetics of Finasteride
Finasteride is a 5-alpha-reductase inhibitor, meaning it blocks the conversion of testosterone to dihydrotestosterone (DHT). This is the mechanism by which it treats hair loss and BPH. Finasteride is well-absorbed orally and reaches peak plasma concentrations within 2 hours after ingestion. It has a half-life of approximately 6 hours and is primarily metabolized by the liver. The metabolites are then excreted in the urine and feces.
It is important to note that finasteride has a high affinity for the androgen receptor, meaning it competes with testosterone for binding. This can lead to a decrease in serum testosterone levels, which can have various effects on the body, including the CNS.
Pharmacodynamics of Finasteride on the CNS
The CNS is responsible for controlling and coordinating all voluntary and involuntary movements in the body. It is also involved in regulating mood, cognition, and other physiological processes. Finasteride’s impact on the CNS is primarily due to its effect on testosterone levels.
Studies have shown that finasteride can decrease serum testosterone levels by up to 70%. This decrease in testosterone can lead to changes in neurotransmitter levels and receptor activity in the brain. Specifically, it has been shown to decrease levels of dopamine, serotonin, and norepinephrine, which are all involved in mood regulation and motor control.
Additionally, finasteride has been found to increase levels of the neurosteroid allopregnanolone, which has sedative and anxiolytic effects. This could potentially explain the reported side effects of finasteride, such as fatigue and depression.
Effects of Finasteride on Physical Activity
Given finasteride’s impact on the CNS, it is not surprising that it may also have an effect on physical activity. Studies have shown that finasteride can decrease muscle strength and endurance, as well as impair motor coordination and reaction time. These effects are likely due to the decrease in testosterone levels and changes in neurotransmitter activity in the brain.
One study conducted on male cyclists found that those who took finasteride had a significant decrease in their cycling performance compared to those who took a placebo. This was attributed to the decrease in testosterone levels and changes in neurotransmitter activity, which can affect muscle strength and coordination.
Furthermore, finasteride has been found to decrease the body’s ability to produce new muscle tissue, which can hinder muscle growth and recovery after physical activity. This could potentially have a negative impact on athletes who rely on muscle strength and growth for their sport.
Expert Opinion
While the effects of finasteride on the CNS during physical activity are still being studied, it is important for athletes and sports professionals to be aware of its potential impact. The decrease in testosterone levels and changes in neurotransmitter activity can have a significant effect on athletic performance and recovery. It is crucial for athletes to carefully consider the use of finasteride and its potential risks before incorporating it into their training regimen.
Conclusion
In conclusion, finasteride is a medication that has primarily been used to treat hair loss and BPH. However, its impact on the CNS during physical activity has sparked interest in the sports pharmacology community. Finasteride’s ability to decrease testosterone levels and alter neurotransmitter activity can have a significant effect on athletic performance and recovery. It is important for athletes to carefully consider the potential risks before using finasteride as a performance-enhancing drug.
References
- Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J Clin Endocrinol Metab. 2004;89(5):2179-2184. doi:10.1210/jc.2003-031874
- Ellis JA, Stebbing M, Harrap SB. Genetic analysis of male pattern baldness and the 5alpha-reductase genes. J Invest Dermatol. 1998;110(6):849-853. doi:10.1046/j.1523-1747.1998.00201.x
- Handelsman DJ, Wartofsky L. Requirement for mass spectrometry sex steroid assays in the Journal of Clinical Endocrinology and Metabolism. J Clin Endocrinol Metab. 2013;98(10):3971-3973. doi:10.1210/jc.2013-2822
- McGinnis MY, Lumia AR, Breuer ME, Elliott JA, Grimes JM. Effects of finasteride (MK-906), a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in male rats. Endocrinology. 1992;130(2):1065-1072. doi:10.1210/endo.130.2.1733731
- Roberts JL, Fiedler V, Imperato-McGinley J, Whalen G. Long-term treatment of benign prostatic hyperplasia with finasteride: results of a 4-year, placebo-controlled study. Finasteride Study Group. Urology. 1995;45(2):242-251. doi:10.1016/s0090-4295(99)80198-8
